When the doctor needs a new heart valve

About one in every 20 people over age 65 has a stiff, narrowed aortic valve. A Harvard physician describes his experience with this condition, called aortic stenosis, from the heart murmur detected at age 66 to his open-heart surgery a decade later. After his diagnosis, he received echocardiograms every one to two years to check the valve, and later a stress echocardiogram. Because the echocardiogram revealed an aortic aneurysm, he had open-heart surgery so the surgeon could repair the valve and the aneurysm during the same operation.

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Stand up for your heart

A 2025 study found that people who are sedentary for 10.6 hours per day or more may face a higher risk of heart failure or dying from heart disease—even if they follow recommended exercise guidelines. Uninterrupted sitting has harmful effects on metabolism, leading the body to burn fewer calories and less fat. It can also cause blood sugar levels to rise, triggering the release of insulin, the hormone that regulates blood sugar. Over time, sedentary habits cause the body to become less sensitive to insulin. The resulting insulin resistance promotes inflammation, a key player in the buildup of fatty plaque inside arteries.

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Cushing’s: A master of disguise

Cushing’s is marked by elevated blood levels of the hormone cortisol. Far more common in women, the condition is categorized as a disease or syndrome based on what factors trigger it, which can include using corticosteroids or having a tumor on the brain’s pituitary gland or elsewhere. Symptoms include a swollen face, excess belly weight, fatigue, a fatty hump between the shoulders, stretch marks, easy bruising, and slow wound healing. Cushing’s can also lead to health problems such as cardiovascular disease, bone loss, and diabetes.

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Unlocking the secrets of super-agers

Super-agers are people who reach their 80s, 90s, or beyond with the memory capacity of someone at least three decades younger. As people get older, certain brain regions shrink, slowing brain functions. But super-agers retain more brain volume in areas linked to memory and movement, and their brains shrink more slowly over time. Women are more likely to be super-agers because they live, on average, longer than men. Genetics also appear to play a significant role in achieving super-ager status.

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