How long does piriformis syndrome take to go away?

The duration of piriformis syndrome is highly variable. For some, it lasts only a few days while for others it can last months. The reason for this variability is not always clear but may depend on the cause (especially overuse), treatment, activity level, and the general health of the affected person. Rest is an essential part of treatment; resuming the activity that triggered piriformis syndrome too soon tends to cause it to last longer.