What is the difference between malaise and fatigue?

Malaise is the medical term for a general feeling of being unwell. Fatigue is a relative term, meaning each of us evaluate our current energy level based upon how we feel most of the time. For example, people who are very energetic and go nonstop from early morning to late at night might say they have fatigue if they felt like most of us do every day. While they can occur separately, fatigue and malaise often go together.