What are the different ways to treat depression?

The most helpful treatment is a combination of psychotherapy and medication. Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed first. They include fluoxetine, sertraline, paroxetine, citalopram and escitalopram. Other effective antidepressants include bupropion, venlafaxine, mirtazapine and duloxetine.

A number of psychotherapy techniques have been demonstrated to be effective. A technique called cognitive behavioral therapy is designed to help a depressed person recognize negative thinking and teaches techniques for controlling symptoms. Psychodynamic, insight-oriented or interpersonal psychotherapy can help depressed people to sort out conflicts in important relationships or explore the history behind symptoms. 

Options for severe or persistent depression despite the usual medications include electroconvulsive therapy (ECT), ketamine and transcranial medical stimulation.