When fear strikes the heart: Post-traumatic stress disorder

People with post-traumatic stress disorder (PTSD) are especially vulnerable to cardiovascular problems, including a 40% increased risk of heart attack. The amygdala, a brain structure involved in processing anxiety, fear, and stress, is overactive in people with PTSD. But these people also have decreased activity in the ventromedial prefrontal cortex, which is responsible for regulating emotions and dampening the fear response. This brain activity imbalance triggers chronic activation of the body’s “fight-or-flight” response. The resulting physiological changes appear to underlie the development of atherosclerosis.