Tracking How Red Wine Chemical Works

U.S. government researchers think they may have found out how a chemical in red wine appears to confer health benefits. The research looks at resveratrol. This chemical is found in red wine and some other plant products. Researchers from the National Institutes of Health traced how it acts in cells. They found that it interferes with the activity of a protein in muscle called PDE4. This protein helps to regulate cell energy. The drug rolipram is also known to interfere with PDE4. So researchers gave this drug to mice. They found that this produced the same results as resveratrol has in other studies. Mice were less likely to get fat. Their bodies were able to make better use of glucose, which can help prevent diabetes. They also were able to exercise longer. Knowing how resveratrol works may help researchers to develop drugs with the same effects.