The five factors that drive heart disease

A 2025 study finds that smoking and high blood pressure are the two most important factors driving heart disease risk. Together with high cholesterol, excess weight (or being underweight), and diabetes, these five factors account for about 50% of the burden of cardiovascular disease. Compared to people with all five risk factors at age 50, those who had none of the factors were far less likely to develop cardiovascular disease or die early. On average, women with none of the risks at midlife lived 13 more years without heart disease, while men lived an additional 11 years.