Non-Antibiotic Drug May Help Fight TB

A drug that attacks tuberculosis (TB) in a new way has shown promise in a new study. The new drug is not an antibiotic. More and more TB bacteria resist common antibiotics. The study included 481 people with TB that was resistant to several antibiotics. They were randomly divided into 3 groups. All groups received treatment according to current guidelines for drug-resistant TB. Two groups also received delamanid, in different doses. Delamanid reduces production of mycolic acid, a key part of TB bacteria. Everyone got regular cultures of sputum that they coughed up. After 8 weeks of treatment, sputum tests showed no TB bacteria in 45% of those taking the lower dose of delamanid. Results from a higher dose were similar. About 30% of those on standard treatment were free of TB bacteria.