New hope for an inherited form of heart disease

Hypertrophic cardiomyopathy (HCM), the most common form of inherited heart disease, is thought to affect one in 500 people. It can be challenging to diagnose because the symptoms vary widely and are sometimes mistaken for other disorders. Many people with HCM have no symptoms or only mild ones for most of their lives. Others notice breathlessness, fatigue, or chest pain, or they have episodes of fainting or near-fainting (particularly during exertion). The disease is passed from one generation to the next by way of dominant-acting mutations in genes that govern the structure of the heart muscle.