IBS in the crosshairs

Irritable bowel syndrome (IBS) affects up to 45 million Americans, two-thirds of whom are women. IBS is categorized into three types depending on which symptoms dominate: diarrhea, constipation, or a mix of both. Possible contributors include changes in gut bacteria, faulty nerve signals between brain and intestine, pelvic floor problems, and genetics. Newer treatment approaches target pathways involved in symptoms. Doctors are also repurposing older drugs for IBS, including certain antidepressants and the antibiotic rifaximin (Xifaxan).