Gene editing: A one-time fix for dangerously high cholesterol?

A gene editing technique that permanently shuts down a cholesterol-raising protein called PCSK9 is being tested in heart attack survivors with an inherited form of high cholesterol. The one-time infusion contains tiny particles that contain the editing tools, which travel through the blood to the liver and changes the cells that produce the protein. If early data show the treatment to be safe and effective, the therapy potentially could be used in people who have “garden variety” high cholesterol.

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Salt shakedown: How and why you should eat less sodium

In addition to raising blood pressure, too much salt in the diet can have other detrimental effects on the heart, including damaging the inner layer of blood vessels and altering the body’s hormonal and inflammatory response. Following the DASH diet, choosing lower-sodium versions of commonly eaten foods, and skipping the saltshaker can help people eat less salt. To boost flavor without salt, options include salt-free herb and spice blends, lemon or lime zest or juice, and flavored vinegars.

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A mask that’s hard to shed

Melasma, which causes dark patches on the face, is far more prevalent in women than in men. Dubbed the “mask of pregnancy,” melasma triggers include not only pregnancy but also hormonal fluctuations, genetics, and sun exposure. People with darker skin are more prone to it. Melasma is typically treated with topical products that lighten the skin or slough off cells. Laser treatments and chemical peels, however, may worsen melasma. Sunscreen use can help prevent flares.

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Anxiety overload

Anxiety often brings physical sensations ranging from dry mouth, nausea, or sweaty hands to more severe symptoms such as dizziness, shortness of breath, or a racing heart. Extreme symptoms can manifest as anxiety attacks and cause people to avoid everyday activities. Cognitive behavioral therapy (CBT) is considered the gold standard treatment for extreme anxiety. One common form of CBT involves exposing people to stressful situations to learn how to cope.

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Short on slumber

Most adults need seven to nine hours of sleep each night, but more than one-third consistently sleep fewer than seven. Reasons for poor sleep include pregnancy, menopausal night sweats, medication use, sleep disorders, and various illnesses. Sleep deprivation can raise the risks for such conditions as diabetes, certain cancers, obesity, dementia, depression, and heart disease. To promote sounder sleep, people can keep consistent sleep-wake schedules, reduce intake of caffeine and alcohol, and avoid using electronic devices before bed.

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