Treating advanced prostate cancer

Most men with prostate cancer have low-grade cancer, meaning the cancer is unlikely to spread or affect quality of life or longevity. But men whose initial prostate biopsy shows an intermediate-risk or high-risk cancer, or those who began active surveillance for low-risk cancer but develop a rising PSA or new symptoms suggesting aggressive cancer, have several treatment options available. These include different combinations of radiation, surgery, androgen deprivation therapy, chemotherapy, immunotherapy, and anti-androgens.

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Investigating memory loss

Sudden memory lapses could be natural aspects of aging or early signs of mild cognitive impairment (MCI). With MCI, memory loss is noticeable but usually does not impede the ability to carry out daily functions. A screening test from a doctor or more advanced testing (such as brain MRI or PET scans) from a neurologist can help identify potential cognitive problems so people can seek appropriate treatment.

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Diagnosing coronary artery disease

People who follow a healthy lifestyle can still have the early stages of coronary artery disease (CAD), the most common type of heart disease. There are many ways people can find out if they have CAD. This includes paying attention to whether exercise causes discomfort, doing a 10-year heart risk assessment, and seeing their doctor for diagnostic testing, such as a coronary artery calcium scan, a resting electrocardiogram, a walking stress test, or an echocardiogram. A doctor uses this information to determine the best treatment path.

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Tips for a high-quality, longer life

We can learn much from people who continue to live productive lives into their 80s and 90s. Doctors in this demographic have a unique perspective as they have the lessons from their decades of medical practice and their personal experiences dealing with Father Time. Here, two Harvard physicians — Dr. Marshall Wolf, 87, and Dr. Mitchell Rabkin, 94 — share lessons they’ve learned over the decades from their practice and personal life about how they keep their body and mind strong, healthy, and thriving.

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A heart disease trigger that lurks inside bone marrow

A condition caused by spontaneous genetic mutations in bone marrow cells, known as clonal hematopoiesis of indeterminate significance (CHIP), is linked to an increased risk of cardiovascular disease. Some of these mutations are clearly related to inflammation, a well-known contributor to the buildup of fatty plaque inside arteries. Experts hope that future research on CHIP will eventually lead to genetically directed therapies to address the condition.

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Practical pointers for pickleballers

Playing pickleball can boost cardiovascular health, but this popular sport can leave older players prone to injuries. Preventive strategies including taking a class to learn proper form; choosing supportive gear such as well-fitting shoes and sleeve braces; warming up before playing with squats, lunges, and heel raises; and doing lower-body strength-building exercises a couple of times per week.

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