Added to Statin, New Drug Cuts LDL More

A new, injectable drug appears to safely reduce LDL cholesterol, even in people already taking statins, researchers report. The new study was an early test for a type of drug known as a monoclonal antibody. It has to enter the bloodstream through an injection or an intravenous (IV) infusion. The new drug, called REGN727, interferes with an enzyme that keeps the liver from removing LDL from the bloodstream. The study had two parts. The first part, using 72 healthy volunteers, found no safety problems. The second part included 51 people who took a statin but still had high LDL cholesterol. Of these, 21 people had an inherited form and 30 had the usual form. Another 10 people had high LDL but were trying to lower it with diet and exercise only. Everyone received 3 injections within 6 weeks. They received either REGN727 or a placebo.