What kind of reaction can you expect from the shingles vaccine?

The Shingrix vaccine decreases the risk of developing shingles (herpes zoster), a painful and potentially serious condition. In some people, the reaction to Shingrix includes mild soreness, redness, swelling, or pain in the arm at the injection site. Some people also experience fatigue, headache, muscle achiness, stomach pain, nausea, fever, or chills and shivering for a day or two. Very rarely, people have an allergic reaction. There is no evidence that anything will prevent a reaction to Shingrix.