Sugar substitutes: New cardiovascular concerns?

People who use artificial sweeteners such as aspartame (NutraSweet, Equal), acesulfame potassium (Sunnett, Sweet One), and sucralose (Splenda) may have a higher risk of cardiovascular disease compared with people who avoid these products. These zero-calorie sweeteners might not help people lose weight, and experts postulate that artificial sweeteners may trigger inflammation and alter normal metabolism, the gut microbiome, and blood vessels in ways that promote type 2 diabetes, unhealthy cholesterol levels, and high blood pressure.