Latest Alzheimer’s Drug Fails

In another blow to the potential treatment of Alzheimer’s disease, human testing of a drug called semagacestat has been halted. It was hoped that the drug would block gamma secretase, an enzyme that makes beta amyloid. Beta amyloid is a protein that appears to “clog” the brains of people with Alzheimer’s. The study included more than 1,500 patients with mild to moderate Alzheimer’s. Those taking the test drug had a faster mental decline than people taking the placebo or fake medicine. Those on the test drug also had serious side effects. But there is a silver lining. The drug maker, Eli Lilly, made all its results public. This can help other researchers. The study appeared in the New England Journal of Medicine. Health Day News wrote about it on July 24.