Acetaminophen vs. ibuprofen: Which should you take?

Acetaminophen and ibuprofen are effective pain relievers that work differently in the body and have different risks associated with their use. Acetaminophen is thought to change how the nervous system senses pain and also helps to reduce fever. Side effects include a risk of liver damage and, in some cases, high blood pressure. Ibuprofen blocks enzymes involved in the process that creates inflammation and pain. The medication’s risks include kidney damage, stomach irritation, bleeding or ulcers, and heart attack or stroke.