What is the best treatment for a blister?

Blisters happen most often from friction or a second-degree burn. Friction blisters occur from skin rubbing on skin or another object. Friction blisters can heal on their own once the frictional force is eliminated or they can be punctured after gently cleaning the surface with alcohol. Leave the covering intact to prevent infection. Regarding blisters due to a burn, it’s best to not puncture it to avoid introducing infection.